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CD79a Antikörper (B-cell antigen receptor complex-associated protein alpha chain) AA 202-216 (FITC) Primary Antibody

CD79A Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh), Meerschweinchen, Pferd, Opossum, Schwein, Kaninchen FACS, IHC (fro), IHC (p) Wirt: Maus Monoclonal HM57 FITC
Pubmed (6 references)
Produktnummer ABIN1302907
$417.45
Zzgl. Versandkosten $45.00
100 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle CD79a (CD79A) Antikörper anzeigen
    CD79a (CD79A)
    Bindungsspezifität
    • 108
    • 31
    • 11
    • 9
    • 9
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 202-216
    Reaktivität
    • 237
    • 129
    • 108
    • 63
    • 62
    • 52
    • 22
    • 20
    • 20
    • 20
    • 17
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Human, Maus, Ratte, Huhn, Rind (Kuh), Meerschweinchen, Pferd, Opossum, Schwein, Kaninchen
    Wirt
    • 128
    • 126
    • 1
    Maus
    Klonalität
    • 153
    • 101
    • 1
    Monoklonal
    Konjugat
    • 103
    • 19
    • 17
    • 13
    • 11
    • 8
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD79a Antikörper ist konjugiert mit FITC
    Applikation
    • 153
    • 117
    • 109
    • 69
    • 59
    • 40
    • 34
    • 15
    • 7
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    The antibody HM57 interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
    HLDA V, WS Code BC cB018
    HLDA VI, WS Code BP 193
    HLDA VI, WS Code BP 89
    HLDA VI, WS Code B B103
    HLDA VI, WS Code B CD79.4
    Kreuzreaktivität (Details)
    Human, Porcine, Mouse, Rat, Bovine, Equine (Horse), Guinea pig, Opossum, Rabbit, Chicken, Other not determined
    Immunogen
    Synthetic peptide corresponding to amino acids 202-216 of human CD79a
    Klon
    HM57
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Faldyna, Samankova, Leva, Cerny, Oujezdska, Rehakova, Sinkora: "Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 56-62, (2007) (PubMed).

    Mason, Cordell, Brown, Borst, Jones, Pulford, Jaffe, Ralfkiaer, Dallenbach, Stein: "CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples." in: Blood, Vol. 86, Issue 4, pp. 1453-9, (1995) (PubMed).

    Jones, Cordell, Beyers, Tse, Mason: "Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 12, pp. 5429-35, (1993) (PubMed).

    Mason, van Noesel, Cordell, Comans-Bitter, Micklem, Tse, van Lier, van Dongen: "The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation." in: European journal of immunology, Vol. 22, Issue 10, pp. 2753-6, (1992) (PubMed).

    Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).

    van Noesel, van Lier, Cordell, Tse, van Schijndel, de Vries, Mason, Borst: "The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 11, pp. 3881-8, (1991) (PubMed).

  • Target
    CD79a (CD79A)
    Andere Bezeichnung
    CD79a (CD79A Produkte)
    Synonyme
    CD79A, Ig-alpha, Iga, Igalpha, Ly-54, Ly54, mb-1, IGA, MB-1, IG-alpha, CD79a molecule, CD79A antigen (immunoglobulin-associated alpha), Cd79a molecule-like, CD79A, Cd79a, Cd79al
    Hintergrund
    CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
    Pathways
    BCR Signaling
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