CD74 Antikörper

Produktnummer ABIN2739636

Produktdetails anti-CD74 Antikörper

Target: CD74 (HLA-DR-gamma (CD74))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD74 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Human CD74

Aufreinigung: Protein G purified

Immunogen: The B lymphoblastoid cell line HFB1.

Type of Immunogen: Cells

Klon: BU45

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, Flo (0.5 - 1 μg/10 x10⁶), IF (1 - 2 μg/mL), IHC, IHC-Fr (0.5 - 1 μg/mL), IP, WB (0.5 - 1 μg/mL)

Usage: This antibody recognizes proteins of 33, 35 and 41  kDa, which are identified as various isoforms of CD74. The CD74 antibody epitope is localized in the extracellular domain of CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinomas. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. CD74 antibody stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. CD74 antibody has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+). ELISA: Order BSA-free format for coating.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C to 8°C.

Details zu CD74

Target: CD74 (HLA-DR-gamma (CD74))

Andere Bezeichnung: CD74 / CLIP (CD74 Produkte)

Synonyme: DHLAG antikoerper, HLADG antikoerper, II antikoerper, Ia-GAMMA antikoerper, CLIP antikoerper, Ii antikoerper, INVG34 antikoerper, Iclp-1 antikoerper, iclp1 antikoerper, wu:fb11f09 antikoerper, wu:fb12a01 antikoerper, wu:fb13d06 antikoerper, wu:fk94e07 antikoerper, Iclp-2 antikoerper, cd74 antikoerper, iclp2 antikoerper, zgc:123161 antikoerper, CD74 molecule antikoerper, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain a antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain b antikoerper, CD74 antikoerper, Cd74 antikoerper, cd74a antikoerper, cd74b antikoerper

Hintergrund: Name/Gene ID: CD74

Synonyms: CD74, CD74 antigen, DHLAG, HLADG, HLA-DR-gamma, Ia-associated invariant chain, p33, MHC HLA-DR gamma chain, Ia-GAMMA

Gen-ID: 972

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints