TGFA Antikörper

Produktnummer ABIN271847

Produktdetails anti-TGFA Antikörper

Target: TGFA (Transforming Growth Factor, alpha (TGFA))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of TGF alpha protein. (region surrounding Arg139)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TGFA

Target: TGFA (Transforming Growth Factor, alpha (TGFA))

Andere Bezeichnung: TGF-alpha (TGFA) (TGFA Produkte)

Synonyme: TFGA antikoerper, LOC100009482 antikoerper, TGF alpha antikoerper, TGFA antikoerper, wa-1 antikoerper, wa1 antikoerper, RATTGFAA antikoerper, TGFAA antikoerper, NV15606 antikoerper, si:ch211-10e8.7 antikoerper, transforming growth factor alpha antikoerper, transforming growth factor alpha L homeolog antikoerper, transforming growth factor-alpha antikoerper, transforming growth factor, alpha antikoerper, TGFA antikoerper, TGF-A antikoerper, Tgfa antikoerper, tgfa.L antikoerper, LOC100121300 antikoerper, LOC100009150 antikoerper, tgfa antikoerper

Hintergrund: Transforming growth factor alpha (TGFalpha) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFalpha is 33 % homologous at the amino acid level to epidermal growth factor (EGF). TGFalpha binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor beta. TGFalpha is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFalpha bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.Synonyms: EGF-like TGF, ETGF, TGF type 1, Transforming growth factor alpha

Molekulargewicht: approx. 10, 17 kDa

Gen-ID: 7039

NCBI Accession: NP_001093161

UniProt: P01135

Pathways: NF-kappaB Signalweg, RTK Signalweg, EGFR Signaling Pathway