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TNFRSF18 Antikörper
TNFRSF18
Reaktivität: Human
IF, ICFC
Wirt: Maus
Monoclonal
621
unconjugated
Produktnummer ABIN2664611
Produktdetails anti-TNFRSF18 Antikörper
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Target
Alle TNFRSF18 Antikörper anzeigen
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Reaktivität
Alle Reaktivitäten für TNFRSF18 Antikörper
Human
Wirt
Alle Wirte für TNFRSF18 Antikörper
Maus
Klonalität
Alle Klonalitäten für TNFRSF18 Antikörper
Monoklonal
Konjugat
Alle Konjugate für TNFRSF18 Antikörper
Dieser TNFRSF18 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TNFRSF18 Antikörper
Immunofluorescence (IF), Intracellular Flow Cytometry (ICFC)
Aufreinigung
The antibody was purified by affinity chromatography.
Klon
621
Isotyp
IgG1 kappa
Top Product
Discover our top product TNFRSF18 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
The antibody solution should be stored undiluted between 2°C and 8°C.
Details zu TNFRSF18
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Target
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Andere Bezeichnung
CD357 (TNFRSF18 Produkte )
Synonyme
GITR antikoerper, TNFRSF18 antikoerper, AITR antikoerper, Gitr antikoerper, CD357 antikoerper, GITR-D antikoerper, TNF receptor superfamily member 18 antikoerper, tumor necrosis factor receptor superfamily, member 18 antikoerper, TNFRSF18 antikoerper, Tnfrsf18 antikoerper
Hintergrund
GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets.
Pathways
Cancer Immune Checkpoints
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