KLRA1 Antikörper (PE)

Produktnummer ABIN2663821

Produktdetails anti-KLRA1 Antikörper (PE)

Target: KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser KLRA1 Antikörper ist konjugiert mit PE

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Klon: YE1-48-10-6

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu KLRA1

Target: KLRA1 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 1 (KLRA1))

Andere Bezeichnung: Ly-49A (KLRA1 Produkte)

Synonyme: Klra2 antikoerper, Ly49i8 antikoerper, A1 antikoerper, Klra22 antikoerper, Ly49a antikoerper, Ly49o<129> antikoerper, Ly49v antikoerper, LY49 antikoerper, KLRA1 antikoerper, Ly49 antikoerper, killer cell lectin-like receptor, subfamily A, member 1 antikoerper, killer cell lectin-like receptor subfamily A, member 1 antikoerper, Klra1 antikoerper, KLRA1 antikoerper, LY49 antikoerper

Hintergrund: Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.