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TNFRSF18 Antikörper (FITC)
TNFRSF18
Reaktivität: Maus
FACS, WB, IHC
Wirt: Ratte
Monoclonal
YGITR 765
FITC
Produktnummer ABIN2661689
Produktdetails anti-TNFRSF18 Antikörper (FITC)
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Target
Alle TNFRSF18 Antikörper anzeigen
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Reaktivität
Alle Reaktivitäten für TNFRSF18 Antikörper
Maus
Wirt
Alle Wirte für TNFRSF18 Antikörper
Ratte
Klonalität
Alle Klonalitäten für TNFRSF18 Antikörper
Monoklonal
Konjugat
Alle Konjugate für TNFRSF18 Antikörper
Dieser TNFRSF18 Antikörper ist konjugiert mit FITC
Applikation
Alle Applikationen für TNFRSF18 Antikörper
Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC)
Aufreinigung
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Klon
YGITR 765
Isotyp
IgG2b kappa
Top Product
Discover our top product TNFRSF18 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Protect from prolonged exposure to light. Do not freeze.
Lagerung
4 °C
Informationen zur Lagerung
The antibody solution should be stored undiluted between 2°C and 8°C.
Details zu TNFRSF18
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Target
TNFRSF18
(Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
Andere Bezeichnung
CD357 (TNFRSF18 Produkte )
Synonyme
GITR antikoerper, TNFRSF18 antikoerper, AITR antikoerper, Gitr antikoerper, CD357 antikoerper, GITR-D antikoerper, TNF receptor superfamily member 18 antikoerper, tumor necrosis factor receptor superfamily, member 18 antikoerper, TNFRSF18 antikoerper, Tnfrsf18 antikoerper
Hintergrund
GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+ CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
Pathways
Cancer Immune Checkpoints
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