COPS3 Antikörper

Produktnummer ABIN265485

Produktdetails anti-COPS3 Antikörper

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of JAB1/COPS3 protein. (region surrounding Met408)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Andere Bezeichnung: COPS3 (COPS3 Produkte)

Synonyme: CG18332 antikoerper, CH3 antikoerper, Csn3 antikoerper, DCH3 antikoerper, Dch3 antikoerper, Dmel\\CG18332 antikoerper, FBgn0027055 antikoerper, dCSN3 antikoerper, COPS3 antikoerper, CSN3 antikoerper, DKFZp468P1922 antikoerper, Sgn3 antikoerper, wu:fc32a02 antikoerper, wu:fk59f01 antikoerper, zgc:111903 antikoerper, zgc:55643 antikoerper, zgc:77615 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 13 antikoerper, COP9 SIGNALOSOME SUBUNIT 3 antikoerper, F18O22.40 antikoerper, F18O22_40 antikoerper, FUS11 antikoerper, FUSCA 11 antikoerper, SGN3 antikoerper, csn3 antikoerper, COP9 signalosome subunit 3 antikoerper, Proteasome component (PCI) domain protein antikoerper, COP9 signalosome subunit 3 L homeolog antikoerper, COP9 signalosome complex subunit 3 antikoerper, CSN3 antikoerper, cops3 antikoerper, COPS3 antikoerper, Cops3 antikoerper, COP13 antikoerper, cops3.L antikoerper, csn-3 antikoerper

Hintergrund: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Junactivation domain-binding protein), interacts with c-Jun and Jun D, but not with Jun B or v-Jun. This interaction enhances the transactivating ability of Jun proteins by stabilizing their binding to the TRE.Synonyms: COP9 signalosome complex subunit 3, CSN3, JAB1-containing signalosome subunit 3, SGN3, Signalosome subunit 3

Molekulargewicht: approx. 47 kDa

Gen-ID: 8533

NCBI Accession: NP_001186054

UniProt: Q9UNS2

Pathways: Zellzyklus