GLUT1 Antikörper

Produktnummer ABIN265442

Produktdetails anti-GLUT1 Antikörper

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of GLUT1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GLUT1

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Andere Bezeichnung: GLUT1 / SLC2A1 (SLC2A1 Produkte)

Synonyme: DYT17 antikoerper, DYT18 antikoerper, DYT9 antikoerper, EIG12 antikoerper, GLUT antikoerper, GLUT1 antikoerper, GLUT1DS antikoerper, HTLVR antikoerper, PED antikoerper, Glut-1 antikoerper, Glut1 antikoerper, GLUTB antikoerper, GTG1 antikoerper, Gtg3 antikoerper, RATGTG1 antikoerper, SLC2A1 antikoerper, GLT1 antikoerper, GLUCOSE TRANSPORTER 1 antikoerper, T21H19.70 antikoerper, T21H19_70 antikoerper, plastidic GLC translocator antikoerper, glut1 antikoerper, ped antikoerper, slc2a1 antikoerper, slc2a14 antikoerper, solute carrier family 2 member 1 antikoerper, solute carrier family 2 (facilitated glucose transporter), member 1 antikoerper, plastidic GLC translocator antikoerper, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog antikoerper, SLC2A1 antikoerper, Slc2a1 antikoerper, PGLCT antikoerper, slc2a1.L antikoerper

Hintergrund: Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve pass transmembrane proteins (12TM) whose carboxytermini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.Synonyms: GLUT-1, Glucose Transporter 1, Glucose transporter type 1, Glucose transporter type 1 erythrocyte/brain, HepG2 glucose transporter, Solute carrier family 2 facilitated glucose transporter member 1

Molekulargewicht: approx. 55 kDa

Gen-ID: 6513

NCBI Accession: NP_006507

UniProt: P11166

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, Warburg Effekt