GLUT1 Antikörper (AA 92-492)

Produktnummer ABIN3043927

Produktdetails anti-GLUT1 Antikörper

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Bindungsspezifität: AA 92-492

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLUT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Verwendungszweck: Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 1(SLC2A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 1(SLC2A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: solute carrier family 2 (facilitated glucose transporter), member 1
Protein Name: Solute carrier family 2, facilitated glucose transporter member 1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SLC2A1 recombinant protein (Position: R92-V492). Human SLC2A1 shares 98% and 98.3% amino acid (aa) sequence identity with mouse and rat SLC2A1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for SLC2A1 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) , IHC(F) and ICC.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-GLUT1 Antikörper (ABIN3043927)

Li, Zhao, Qi, Wang, Zhang, Li, Qin: "lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma." in: International journal of oncology, Vol. 53, Issue 2, pp. 551-566, (2018) (PubMed).

Details zu GLUT1

Target: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Andere Bezeichnung: SLC2A1 (SLC2A1 Produkte)

Synonyme: DYT17 antikoerper, DYT18 antikoerper, DYT9 antikoerper, EIG12 antikoerper, GLUT antikoerper, GLUT1 antikoerper, GLUT1DS antikoerper, HTLVR antikoerper, PED antikoerper, Glut-1 antikoerper, Glut1 antikoerper, GLUTB antikoerper, GTG1 antikoerper, Gtg3 antikoerper, RATGTG1 antikoerper, SLC2A1 antikoerper, GLT1 antikoerper, GLUCOSE TRANSPORTER 1 antikoerper, T21H19.70 antikoerper, T21H19_70 antikoerper, plastidic GLC translocator antikoerper, glut1 antikoerper, ped antikoerper, slc2a1 antikoerper, slc2a14 antikoerper, solute carrier family 2 member 1 antikoerper, solute carrier family 2 (facilitated glucose transporter), member 1 antikoerper, plastidic GLC translocator antikoerper, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog antikoerper, SLC2A1 antikoerper, Slc2a1 antikoerper, PGLCT antikoerper, slc2a1.L antikoerper

Hintergrund: GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.

Synonyms: DYT17 antibody|DYT18 antibody|erythrocyte/brain antibody|Erythrocyte/brain HepG2 glucose transporter antibody|Erythrocyte/hepatoma glucose transporter antibody|facilitated glucose transporter member 1 antibody|Glucose transporter 1 antibody|Glucose transporter type 1 antibody|Glucose transporter type 1 erythrocyte/brain antibody|Glucose transporter type 1, erythrocyte/brain antibody|GLUT antibody|GLUT-1 antibody|GLUT1 antibody|GLUT1DS antibody| GLUTB antibody|GT1 antibody|GTG1 antibody|Gtg3 antibody|GTR1_HUMAN antibody|HepG2 glucose transporter antibody|MGC141895 antibody|MGC141896 antibody|PED antibody|RATGTG1 antibody| SLC2A 1 antibody|SLC2A1 antibody|Solute carrier family 2 (facilitated glucose transporter), member 1 antibody|Solute carrier family 2 antibody|Solute carrier family 2 facilitated glucose transporter member 1 antibody|Solute carrier family 2, facilitated glucose transporter member 1 antibody

Gen-ID: 6513

UniProt: P11166

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, Warburg Effekt