SYK Antikörper (AA 5-360)

Produktnummer ABIN2573229

Produktdetails anti-SYK Antikörper

Target: SYK (Spleen tyrosine Kinase (SYK))

Bindungsspezifität: AA 5-360

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SYK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marke: IHC-plus™

Spezifität: Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.

Aufreinigung: Protein A purified

Immunogen: Recombinant fragment corresponding to amino acids 5 - 360 of human Syk.

Type of Immunogen: Recombinant protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P (10 μg/mL), IP, WB

Usage: Western Blot: Detects a band of approximately 72kD in Ramos and RBL cell lysates.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Details zu SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Andere Bezeichnung: SYK (SYK Produkte)

Synonyme: p72-Syk antikoerper, Sykb antikoerper, p72syk antikoerper, spleen associated tyrosine kinase antikoerper, spleen tyrosine kinase antikoerper, syk antikoerper, SYK antikoerper, Syk antikoerper

Hintergrund: Name/Gene ID: SYK
Subfamily: Syk/ZAP70
Family: Protein Kinase

Synonyms: SYK, p72syk, Spleen tyrosine kinase, Syk protein-tyrosine kinase, Tyrosine-protein kinase SYK, p72-Syk

Gen-ID: 6850

Pathways: Fc-epsilon Rezeptor Signalübertragung, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling