TEK Antikörper (pTyr992)

Produktnummer ABIN2568495

Produktdetails anti-TEK Antikörper

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Bindungsspezifität: pTyr992

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TEK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The Antibody detects endogenous levels of TIE2 only when phosphorylated at Tyr992.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: TIE2 (phospho Tyr992) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y (p)-V-K) derived from Human TIE2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Andere Bezeichnung: TIE2 (TEK Produkte)

Synonyme: TEK antikoerper, DKFZp469E064 antikoerper, AA517024 antikoerper, Cd202b antikoerper, Hyk antikoerper, Tie2 antikoerper, tie-2 antikoerper, CD202B antikoerper, TIE-2 antikoerper, TIE2 antikoerper, VMCM antikoerper, VMCM1 antikoerper, Tie-2 antikoerper, tie2 antikoerper, TEK receptor tyrosine kinase antikoerper, angiopoietin-1 receptor antikoerper, TEK tyrosine kinase, endothelial antikoerper, TEK antikoerper, LOC100408334 antikoerper, tek antikoerper, Tek antikoerper

Hintergrund: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Molekulargewicht: 126 kDa

Gen-ID: 7010

NCBI Accession: NP_000450

UniProt: Q02763

Pathways: RTK Signalweg, Growth Factor Binding