PIAS2 Antikörper

Produktnummer ABIN2463619

Produktdetails anti-PIAS2 Antikörper

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PIAS2.

Anwendungsinformationen

Applikationshinweise: PIAS2 antibody can be used for detection of PIAS2 by ELISA at 1:1562500. PIAS2 antibody can be used for detection of PIAS2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PIAS2 antibody at -20 °C.

Details zu PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Andere Bezeichnung: PIAS2 (PIAS2 Produkte)

Synonyme: MGC83751 antikoerper, piasx antikoerper, wu:fi05f09 antikoerper, PIAS2 antikoerper, 6330408K17Rik antikoerper, AI462206 antikoerper, ARIP3 antikoerper, AU018068 antikoerper, Dib antikoerper, Miz1 antikoerper, PIASxalpha antikoerper, PIASxb antikoerper, PIASxbeta antikoerper, SIZ2 antikoerper, DIP antikoerper, MIZ antikoerper, MIZ1 antikoerper, PIASX antikoerper, PIASX-ALPHA antikoerper, PIASX-BETA antikoerper, ZMIZ4 antikoerper, protein inhibitor of activated STAT 2 L homeolog antikoerper, protein inhibitor of activated STAT 2 antikoerper, protein inhibitor of activated STAT, 2 antikoerper, pias2.L antikoerper, PIAS2 antikoerper, pias2 antikoerper, Pias2 antikoerper

Hintergrund: Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.

Molekulargewicht: 63 kDa

Gen-ID: 9063

NCBI Accession: NP_775298

Pathways: JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling