PIAS2 Antikörper (C-Term)

Produktnummer ABIN2779873

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PIAS2 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Hund, Rind (Kuh), Pferd und Kaninchen.

Kurzübersicht für PIAS2 Antikörper (C-Term) (ABIN2779873)

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Reaktivität: Human, Maus, Hund, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PIAS2 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Pias2 Antibody - C-terminal region

Sequenz: LSLIPVDPQY CPPMFLDSLT SPLTASSTSV TTTSPHESST HVSSSSSRSE

Homologie: Cow: 93%, Dog: 100%, Horse: 100%, Human: 93%, Mouse: 100%, Rabbit: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against Pias2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse Pias2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109279

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PIAS2

Target: PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))

Andere Bezeichnung: Pias2

Hintergrund:

Background Information: Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity.

Gene Name: Protein inhibitor of activated STAT 2

Alternative Symbols: Di, PI, DIP, Dib, Miz, Miz1, PIAS, SIZ2, ARIP3, PIASxb, AI462206, AU018068, PIASxbeta, PIASxalpha, PIASxalpha6

Protein Name: E3 SUMO-protein ligase PIAS2

Molekulargewicht: 54kDa

Gen-ID: 17344

UniProt: Q8C5D8

Pathways: JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling