PCBP1 Antikörper
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- Target Alle PCBP1 Antikörper anzeigen
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PCBP1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PCBP1.
- Top Product
- Discover our top product PCBP1 Primärantikörper
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- Applikationshinweise
- PCBP1 antibody can be used for detection of PCBP1 by ELISA at 1:62500. PCBP1 antibody can be used for detection of PCBP1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store PCBP1 antibody at -20 °C.
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- Target
- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
- Andere Bezeichnung
- PCBP1 (PCBP1 Produkte)
- Synonyme
- PCBP1 antikoerper, HNRPE1 antikoerper, HNRPX antikoerper, hnRNP-E1 antikoerper, hnRNP-X antikoerper, hnRNP E1 antikoerper, WBP17 antikoerper, [a]CP-1 antikoerper, alphaCP-1 antikoerper, RGD1561319 antikoerper, poly(rC) binding protein 1 antikoerper, poly(rC) binding protein 1 L homeolog antikoerper, poly(rC)-binding protein 1 antikoerper, PCBP1 antikoerper, pcbp1.L antikoerper, LOC100388387 antikoerper, Pcbp1 antikoerper
- Hintergrund
- PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
- Molekulargewicht
- 39 kDa
- Gen-ID
- 5093
- NCBI Accession
- NP_006187
- UniProt
- Q15365
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