PCBP1 Antikörper (Middle Region)

Produktnummer ABIN2778971

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-PCBP1 Antikörper (ABIN2778971) detektiert spezifisch PCBP1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen und Pferd.

Kurzübersicht für PCBP1 Antikörper (Middle Region) (ABIN2778971)

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Kaninchen, Hund, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PCBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PCBP1 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PCBP1 Antibody - middle region

Sequenz: PHATHDLEGP PLDAYSIQGQ HTISPLDLAK LNQVARQQSH FAMMHGGTGF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PCBP1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human PCBP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8108470

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PCBP1 Antikörper (ABIN2778971)

Shi, Bencze, Stemmler, Philpott: "A cytosolic iron chaperone that delivers iron to ferritin." in: Science (New York, N.Y.), Vol. 320, Issue 5880, pp. 1207-10, (2008) (PubMed).

Details zu PCBP1

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Andere Bezeichnung: PCBP1

Hintergrund:

Background Information: PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Gene Name: Poly(rC) binding protein 1

Alternative Symbols: HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1

Protein Name: Poly(rC)-binding protein 1

Molekulargewicht: 37 kDa

Gen-ID: 5093

NCBI Accession: NP_006187

UniProt: Q15365