NFKBIB Antikörper
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- Target Alle NFKBIB Antikörper anzeigen
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NFKBIB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by peptide affinity chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFKBIB.
- Top Product
- Discover our top product NFKBIB Primärantikörper
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- Applikationshinweise
- NFKBIB antibody can be used for detection of NFKBIB by ELISA at 1:2500. NFKBIB antibody can be used for detection of NFKBIB by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store NFKBIB antibody at -20 °C.
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- Target
- NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))
- Andere Bezeichnung
- NFKBIB (NFKBIB Produkte)
- Synonyme
- NFKBIB antikoerper, IKB-beta antikoerper, IKappaBbeta antikoerper, IkB antikoerper, IkBb antikoerper, IKBB antikoerper, TRIP9 antikoerper, NFKB inhibitor beta antikoerper, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta antikoerper, NFKBIB antikoerper, Nfkbib antikoerper
- Hintergrund
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
- Molekulargewicht
- 38 kDa
- Gen-ID
- 4793
- NCBI Accession
- NP_002494
- UniProt
- Q15653
- Pathways
- NF-kappaB Signalweg, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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