Band 3/AE1 Antikörper

Produktnummer ABIN2460810

Produktdetails anti-Band 3/AE1 Antikörper

Target: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Band 3/AE1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SLC4A1.

Anwendungsinformationen

Applikationshinweise: SLC4A1 antibody can be used for detection of SLC4A1 by ELISA at 1:312500. SLC4A1 antibody can be used for detection of SLC4A1 by western blot at 0.1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SLC4A1 antibody at -20 °C.

Details zu Band 3/AE1

Target: Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

Andere Bezeichnung: SLC4A1 (SLC4A1 Produkte)

Synonyme: AE1 antikoerper, BND3 antikoerper, CD233 antikoerper, DI antikoerper, EMPB3 antikoerper, EPB3 antikoerper, FR antikoerper, RTA1A antikoerper, SW antikoerper, WD antikoerper, WD1 antikoerper, WR antikoerper, Ae1 antikoerper, Empb3 antikoerper, l11Jus51 antikoerper, ae1 antikoerper, band3 antikoerper, MGC152771 antikoerper, zgc:111889 antikoerper, zgc:152771 antikoerper, si:dz180g5.1 antikoerper, LOC100136769 antikoerper, slc4a1 antikoerper, wd1 antikoerper, bnd3 antikoerper, epb3 antikoerper, cd233 antikoerper, empb3 antikoerper, rta1a antikoerper, MGC80391 antikoerper, SLC4A1 antikoerper, BB3 antikoerper, EAT antikoerper, solute carrier family 4 member 1 (Diego blood group) antikoerper, solute carrier family 4 (anion exchanger), member 1 antikoerper, solute carrier family 4 (anion exchanger), member 1a (Diego blood group) antikoerper, Band 3 antikoerper, erythrocyte membrane protein band 4.1 like 3 antikoerper, solute carrier family 4 member 1 (Diego blood group) L homeolog antikoerper, solute carrier family 4 member 1 antikoerper, SLC4A1 antikoerper, Slc4a1 antikoerper, slc4a1a antikoerper, LOC100136769 antikoerper, EPB41L3 antikoerper, slc4a1.L antikoerper, slc4a1 antikoerper

Hintergrund: The CD233 gene is located on chromosome 17q21-q22 and is part of the anion exchanger (AE) family. CD233 is expressed in the erythrocyte plasma membrane where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40 kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. CD233 associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of CD233. CD233 is predominantly dimeric but forms tetramers in the presence of ankyrin. Many CD233 mutations are known in man and these mutations can lead to two types of disease, destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other CD233 mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the CD233 protein and is common in areas where Plasmodium falciparum malaria is endemic. One CD233 null human is known also with very severe anemia and nephrocalcinosis [PROW].

Molekulargewicht: 102 kDa

Gen-ID: 283489

NCBI Accession: NP_000333

UniProt: P02730