GFI1 Antikörper

Produktnummer ABIN2460501

Produktdetails anti-GFI1 Antikörper

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GFI1.

Anwendungsinformationen

Applikationshinweise: GFI1 antibody can be used for detection of GFI1 by ELISA at 1:312500. GFI1 antibody can be used for detection of GFI1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GFI1 antibody at -20 °C.

Details zu GFI1

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Andere Bezeichnung: GFI1 (GFI1 Produkte)

Synonyme: AW495828 antikoerper, Gfi-1 antikoerper, Pal-1 antikoerper, Pal1 antikoerper, GFI1 antikoerper, GFI-1 antikoerper, GFI1A antikoerper, SCN2 antikoerper, ZNF163 antikoerper, growth factor independent 1 antikoerper, growth factor independent 1 transcriptional repressor antikoerper, Gfi1 antikoerper, GFI1 antikoerper

Hintergrund: GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Molekulargewicht: 45 kDa

Gen-ID: 2672

NCBI Accession: NP_005254

UniProt: Q99684