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GFI1 Produkte

(Growth Factor Independent 1 (GFI1))

Kategorien

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

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Ausgewählte GFI1 Kategorien

GFI1 Antikörper

High quality antibodies with extensive validation data.

GFI1 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene GFI1 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation IF, IHC (p), ELISA, WB
Validierungen
  • (5)
Kat. Nr. ABIN561035
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (2)
  • (1)
Kat. Nr. ABIN969174
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ELISA, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7245050
Menge 200 μL
Datenblatt Datenblatt

Empfohlene GFI1 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6222660
Menge 96 tests
Datenblatt Datenblatt

Empfohlene GFI1 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3134645
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3092738
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN2735930
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren GFI1 Produkten

Duran Alonso, Lopez Hernandez, de la Fuente, Garcia-Sancho, Giraldez, Schimmang: "Transcription factor induced conversion of human fibroblasts towards the hair cell lineage." in: PLoS ONE, Vol. 13, Issue 7, pp. e0200210, (2019) (PubMed).

Vadnais, Chen, Fraszczak, Yu, Boulais, Pinder, Frank, Khandanpour, Hébert, Dellaire, Côté, Richard, Orthwein, Drobetsky, Möröy: "GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1." in: Nature communications, Vol. 9, Issue 1, pp. 1418, (2018) (PubMed).

Olsson, Venkatasubramanian, Chaudhri, Aronow, Salomonis, Singh, Grimes: "Single-cell analysis of mixed-lineage states leading to a binary cell fate choice." in: Nature, Vol. 537, Issue 7622, pp. 698-702, (2017) (PubMed).

Fraszczak, Helness, Chen, Vadnais, Robert, Khandanpour, Möröy: "Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1." in: PLoS ONE, Vol. 11, Issue 7, pp. e0160344, (2017) (PubMed).

Northcott, Lee, Zichner, Stütz, Erkek, Kawauchi, Shih, Hovestadt, Zapatka, Sturm, Jones, Kool, Remke, Cavalli, Zuyderduyn, Bader, VandenBerg, Esparza, Ryzhova, Wang, Wittmann, Stark, Sieber et al.: "Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. ..." in: Nature, Vol. 511, Issue 7510, pp. 428-34, (2014) (PubMed).

Dwivedi, Anderson, Tilley, May, Morris: "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells." in: The Journal of steroid biochemistry and molecular biology, Vol. 103, Issue 3-5, pp. 742-6, (2007) (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).

Synonyme und alternative Namen zu GFI1

growth factor independent 1 (Gfi1), growth factor independent 1 transcriptional repressor (GFI1), growth factor independent 1 transcriptional repressor (Gfi1), AW495828, Gfi-1, GFI-1, GFI1, GFI1A, Pal-1, Pal1, SCN2, ZNF163

Bezeichner auf Proteinebene für GFI1

  • growth factor independent protein 1
  • zinc finger protein Gfi-1
  • growth factor independent 1
  • Growth factor independent-1
  • growth factor independence-1
  • zinc finger protein 163
  • growth factor independence 1
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