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Geminin Produkte

(Geminin, DNA Replication Inhibitor (GMNN))
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].

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Ausgewählte Geminin Kategorien

Geminin Antikörper

High quality antibodies with extensive validation data.

Geminin ELISA Kits

Reliable ELISA kits for a wide range of species.

Geminin Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Geminin Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation IF, IHC (p), ELISA, WB
Validierungen
  • (7)
Kat. Nr. ABIN565518
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation FACS, ELISA, WB
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN1574066
Menge 40 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation IF, IHC, StM
Validierungen
  • (3)
Kat. Nr. ABIN6940265
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Geminin ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method
Validierungen
Kat. Nr. ABIN1134607
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method
Validierungen
Kat. Nr. ABIN1134608
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Geminin Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3080639
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3132132
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1355302
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Geminin Produkten

Terré, Piergiovanni, Segura-Bayona, Gil-Gómez, Youssef, Attolini, Wilsch-Bräuninger, Jung, Rojas, Marjanović, Knobel, Palenzuela, López-Rovira, Forrow, Huttner, Valverde, de Bruin, Costanzo, Stracker: "GEMC1 is a critical regulator of multiciliated cell differentiation." in: The EMBO journal, Vol. 35, Issue 9, pp. 942-60, (2016) (PubMed).

Karamitros, Patmanidi, Kotantaki, Potocnik, Bähr-Ivacevic, Benes, Lygerou, Kioussis, Taraviras: "Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors." in: Development (Cambridge, England), Vol. 142, Issue 1, pp. 70-81, (2014) (PubMed).

Tsunematsu, Takihara, Ishimaru, Pagano, Takata, Kudo: "Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis." in: Nature communications, Vol. 4, pp. 1885, (2013) (PubMed).

Wang, Kirschner: "Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex." in: Nature cell biology, Vol. 15, Issue 7, pp. 797-806, (2013) (PubMed).

Yim, Erikson: "Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation." in: Molecular and cellular biology, Vol. 29, Issue 10, pp. 2609-21, (2009) (PubMed).

Pitulescu, Kessel, Luo: "The regulation of embryonic patterning and DNA replication by geminin." in: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 13, pp. 1425-33, (2005) (PubMed).

Luo, Yang, Takihara, Knoetgen, Kessel: "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions." in: Nature, Vol. 427, Issue 6976, pp. 749-53, (2004) (PubMed).

Montanari, Boninsegna, Faraglia, Coco, Giordano, Cittadini, Sgambato: "Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors." in: Journal of cellular physiology, Vol. 202, Issue 1, pp. 215-22, (2004) (PubMed).

ElShamy, Livingston: "Identification of BRCA1-IRIS, a BRCA1 locus product." in: Nature cell biology, Vol. 6, Issue 10, pp. 954-67, (2004) (PubMed).

Eward, Obermann, Shreeram, Loddo, Fanshawe, Williams, Jung, Prevost, Blow, Stoeber, Williams: "DNA replication licensing in somatic and germ cells." in: Journal of cell science, Vol. 117, Issue Pt 24, pp. 5875-86, (2004) (PubMed).

Synonyme und alternative Namen zu Geminin

geminin, DNA replication inhibitor (GMNN), CG3183 gene product from transcript CG3183-RA (geminin), geminin, DNA replication inhibitor (gmnn), geminin (LOC410093), GE24654 gene product from transcript GE24654-RA (Dyak\geminin), geminin (Gmnn), geminin, DNA replication inhibitor (Gmnn), anon-WO0257455.1, AW546347, CG3183, Dmel\\CG3183, Dm Geminin, Dm geminin, DyakGE24654, dyak_GLEANR_833, GB16871, GE24654, Gem, gem, Geminin, geminin, GMNN, l(2)k14019, LOC100049517, sb:cb254, v(2)k09107, zgc:66217

Bezeichner auf Proteinebene für Geminin

  • CG3183-PA
  • CG3183-PB
  • geminin-PA
  • geminin-PB
  • geminin
  • geminin protein
  • geminin, DNA replication inhibitor
  • DyakGE24654-PA
  • Dyakgeminin-PA
  • GE24654-PA
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