RAD17 Antikörper
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- Target Alle RAD17 Antikörper anzeigen
- RAD17
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RAD17 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RAD17.
- Top Product
- Discover our top product RAD17 Primärantikörper
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- Applikationshinweise
- RAD17 antibody can be used for detection of RAD17 by ELISA at 1:62500. RAD17 antibody can be used for detection of RAD17 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Konzentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handhabung
- As with any antibody avoid repeat freeze-thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store RAD17 antibody at -20 °C.
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- Target
- RAD17
- Andere Bezeichnung
- RAD17 (RAD17 Produkte)
- Synonyme
- zgc:91969 antikoerper, RAD17 antikoerper, K2A18.21 antikoerper, K2A18_21 antikoerper, RADIATION SENSITIVE 17 antikoerper, CCYC antikoerper, HRAD17 antikoerper, R24L antikoerper, RAD17SP antikoerper, RAD24 antikoerper, 9430035O09Rik antikoerper, MmRad24 antikoerper, RAD17 checkpoint clamp loader component antikoerper, Rad17p antikoerper, RADIATION SENSITIVE 17 antikoerper, RAD17 antikoerper, rad17 antikoerper, ATRAD17 antikoerper, Rad17 antikoerper
- Hintergrund
- RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.
- Molekulargewicht
- 66 kDa, 76 kDa, 76 kDa, 77 kDa, 57 kDa, 76 kDa, 76 kDa, 76 kDa
- Gen-ID
- 5884
- NCBI Accession
- NP_579919
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