LIN7C Antikörper

Produktnummer ABIN2458686

Produktdetails anti-LIN7C Antikörper

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIN7C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LIN7C.

Anwendungsinformationen

Applikationshinweise: LIN7C antibody can be used for detection of LIN7C by ELISA at 1:312500. LIN7C antibody can be used for detection of LIN7C by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store LIN7C antibody at -20 °C.

Details zu LIN7C

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Andere Bezeichnung: LIN7C (LIN7C Produkte)

Synonyme: LIN7C antikoerper, fb75b09 antikoerper, wu:fb75b09 antikoerper, zgc:101881 antikoerper, LIN-7-C antikoerper, LIN-7C antikoerper, MALS-3 antikoerper, MALS3 antikoerper, VELI3 antikoerper, 9130007B12Rik antikoerper, AI303698 antikoerper, AU019331 antikoerper, AW125731 antikoerper, D2Ertd520e antikoerper, Veli3 antikoerper, lin-7 homolog C, crumbs cell polarity complex component antikoerper, lin-7 homolog C L homeolog antikoerper, lin-7 homolog C (C. elegans) antikoerper, LIN7C antikoerper, lin7c.L antikoerper, lin7c antikoerper, Lin7c antikoerper

Hintergrund: LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Molekulargewicht: 22 kDa

Gen-ID: 55327

NCBI Accession: NP_060832

UniProt: Q9NUP9

Pathways: Synaptic Membrane