PDGFB Antikörper

Produktnummer ABIN2432206

Produktdetails anti-PDGFB Antikörper

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human PDGFB

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Andere Bezeichnung: PDGFB (PDGFB Produkte)

Synonyme: PDGF-2 antikoerper, PDGF2 antikoerper, SIS antikoerper, SSV antikoerper, c-sis antikoerper, pdgf2 antikoerper, sis antikoerper, si:ch211-79m20.1 antikoerper, si:dkey-261d11.1 antikoerper, PDGF-B antikoerper, Sis antikoerper, platelet derived growth factor subunit B antikoerper, platelet-derived growth factor beta polypeptide antikoerper, platelet derived growth factor subunit B S homeolog antikoerper, platelet-derived growth factor beta polypeptide a antikoerper, platelet derived growth factor, B polypeptide antikoerper, PDGFB antikoerper, pdgfb.S antikoerper, pdgfba antikoerper, Pdgfb antikoerper

Hintergrund: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

NCBI Accession: NP_002599

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling