PTAFR Antikörper
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- Target Alle PTAFR Antikörper anzeigen
- PTAFR (Platelet-Activating Factor Receptor (PTAFR))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PTAFR Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC)
- Aufreinigung
- Affinity purification
- Immunogen
- Synthetic peptide of human PTAFR
- Isotyp
- IgG
- Top Product
- Discover our top product PTAFR Primärantikörper
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- Applikationshinweise
- IHC 1:25-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- Konservierungsmittel
- Sodium azide
- Handhabung
- Avoid freeze / thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PTAFR (Platelet-Activating Factor Receptor (PTAFR))
- Andere Bezeichnung
- PTAFR (PTAFR Produkte)
- Synonyme
- PAFR antikoerper, MGC52896 antikoerper, MGC160177 antikoerper, PAFr antikoerper, pafr antikoerper, PAF-R antikoerper, platelet activating factor receptor antikoerper, platelet-activating factor receptor antikoerper, platelet activating factor receptor L homeolog antikoerper, PTAFR antikoerper, Ptafr antikoerper, ptafr.L antikoerper, ptafr antikoerper
- Hintergrund
- This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
- NCBI Accession
- NP_000943
- Pathways
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin
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