Calreticulin Antikörper

Produktnummer ABIN2428194

Produktdetails anti-Calreticulin Antikörper

Target: Calreticulin (CALR)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calreticulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human CALR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:5000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Calreticulin

Target: Calreticulin (CALR)

Andere Bezeichnung: CALR (CALR Produkte)

Synonyme: CRT antikoerper, RO antikoerper, SSA antikoerper, cC1qR antikoerper, crc antikoerper, crt antikoerper, Calregulin antikoerper, CG9429 antikoerper, Clr antikoerper, Dmel\\CG9429 antikoerper, anon-EST:Liang-2.11 antikoerper, anon-EST:Liang-2.17 antikoerper, anon-EST:fe3D7 antikoerper, clone 2.11 antikoerper, clone 2.17 antikoerper, eth antikoerper, potp antikoerper, cc1qr antikoerper, ssa antikoerper, NV19007 antikoerper, CRP55 antikoerper, ERp60 antikoerper, HACBP antikoerper, CHOT1 antikoerper, CHT1 antikoerper, CT1 antikoerper, AA589632 antikoerper, CRTR antikoerper, Creat antikoerper, CCDS1 antikoerper, calrl2 antikoerper, fc66d10 antikoerper, wu:fc66d10 antikoerper, wu:fj50c03 antikoerper, zgc:66153 antikoerper, calreticulin antikoerper, calreticulin L homeolog antikoerper, Calreticulin antikoerper, putative calreticulin antikoerper, solute carrier family 6 member 8 antikoerper, solute carrier family 6 (neurotransmitter transporter, creatine), member 8 antikoerper, CALR antikoerper, calr.L antikoerper, Crt antikoerper, crt antikoerper, CRT antikoerper, Calr antikoerper, calr antikoerper, LMJF_31_2600 antikoerper, Crc antikoerper, Slc6a8 antikoerper, SLC6A8 antikoerper, LOC8269812 antikoerper

Hintergrund: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

Molekulargewicht: Calculated MW: 48 kDa

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response