Aurora Kinase B Antikörper (AA 227-238)

Produktnummer ABIN225421

Produktdetails anti-Aurora Kinase B Antikörper

Target: Aurora Kinase B (AURKB)

Bindungsspezifität: AA 227-238

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aurora Kinase B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Detects Aurora-B kinase (AurB), a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis- one containing all four members, and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumors, including primary breast and colon tumor samples. Its expression in tumors seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to amino acids 227-238 of human Aurora-B kinase.

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (1:2000 - 1:10000), WB (1:250 - 1:1000)

Usage: Western Blot: LS-C42572 detects a band of approximately 39kD in HeLa cell lysates.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Andere Bezeichnung: AURKB / Aurora-B (AURKB Produkte)

Synonyme: AIK2 antikoerper, AIM-1 antikoerper, AIM1 antikoerper, ARK2 antikoerper, AurB antikoerper, IPL1 antikoerper, PPP1R48 antikoerper, STK12 antikoerper, STK5 antikoerper, aurkb-sv1 antikoerper, aurkb-sv2 antikoerper, AIRK2 antikoerper, AL022959 antikoerper, Aik2 antikoerper, Aim1 antikoerper, Ark2 antikoerper, STK-1 antikoerper, Stk12 antikoerper, Stk5 antikoerper, Aur B antikoerper, Aurora B antikoerper, Aurora-B antikoerper, CG6620 antikoerper, DmAIRK2 antikoerper, DmAurB antikoerper, DmAuroraB antikoerper, Dmel\\CG6620 antikoerper, IAL antikoerper, IAL1 antikoerper, Ial antikoerper, aurB antikoerper, aurora B antikoerper, ARK-2 antikoerper, XAIRK2 antikoerper, aik2 antikoerper, aim-1 antikoerper, aim1 antikoerper, airk2 antikoerper, ark2 antikoerper, ipl1 antikoerper, stk12 antikoerper, stk5 antikoerper, CHUNP6896 antikoerper, fa09g06 antikoerper, stka antikoerper, wu:fa09g06 antikoerper, aurkb antikoerper, AIRK2-B antikoerper, XAIRK2-B antikoerper, aurkb-a antikoerper, aurkb-b antikoerper, xAurora-B-B antikoerper, aurora kinase B antikoerper, aurora B antikoerper, aurora kinase B S homeolog antikoerper, AURKB antikoerper, Aurkb antikoerper, aurB antikoerper, aurkb antikoerper, aurkb.S antikoerper

Hintergrund: Name/Gene ID: AURKB
Subfamily: Aurora/IPL1-like
Family: Protein Kinase

Synonyms: AURKB, AIRK2, AIK2, Aurora kinase B, Aurora kinase B-Sv1, Aurora-related kinase 2, Aurora/IPL1-related kinase 2, ARK-2, ARK2, Aurkb-sv1, Aurkb-sv2, Aurora 1, Aurora-B, AIM-1, IPL1, STK-1, STK5, PPP1R48, AurB, Aurora B, Aurora kinase B-Sv2, Aurora-1, Aurora1, Serine/threonine kinase 12, STK1, STK12

Gen-ID: 9212

UniProt: Q96GD4

Pathways: T-Zell Rezeptor Signalweg, Zellzyklus, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades