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IL1RAP Antikörper (AA 251-350) (Biotin)

IL1RAP Reaktivität: Maus ELISA, IHC (p) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN2176997
  • Target Alle IL1RAP Antikörper anzeigen
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Bindungsspezifität
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 251-350
    Reaktivität
    • 31
    • 12
    • 3
    Maus
    Wirt
    • 33
    • 4
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 26
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL1RAP Antikörper ist konjugiert mit Biotin
    Applikation
    • 25
    • 11
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IL1RAP/IL1R3
    Isotyp
    IgG
    Top Product
    Discover our top product IL1RAP Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Andere Bezeichnung
    IL1RAP (IL1RAP Produkte)
    Synonyme
    IL1RAP antikoerper, il-1racp antikoerper, il-racp antikoerper, il1r3 antikoerper, C3orf13 antikoerper, IL-1RAcP antikoerper, IL1R3 antikoerper, 6430709H04Rik antikoerper, AI255955 antikoerper, AV239853 antikoerper, IL-1RAcp antikoerper, Il1racpb antikoerper, interleukin 1 receptor accessory protein antikoerper, IL1RAP antikoerper, il1rap antikoerper, il-1racp antikoerper, Il1rap antikoerper
    Hintergrund

    Synonyms: IL1R3, C3orf13, IL-1RAcP, Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP

    Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

    Gen-ID
    3556
    UniProt
    Q9NPH3
    Pathways
    NF-kappaB Signalweg, Growth Factor Binding
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