IL1RAP Antikörper (AA 484-518)

Produktnummer ABIN6242410

Der Kaninchen Polyklonal anti-IL1RAP Antikörper (Klon RB57769) (ABIN6242410) detektiert spezifisch IL1RAP in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für IL1RAP Antikörper (AA 484-518) (ABIN6242410)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB57769

Produktdetails anti-IL1RAP Antikörper

Bindungsspezifität: AA 484-518

Homologie: H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 484-518 amino acids of human IL1RAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Andere Bezeichnung: IL1RAP

Hintergrund: Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Molekulargewicht: 65418

UniProt: Q9NPH3

Pathways: NF-kappaB Signalweg, Growth Factor Binding