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IL1RAP Antikörper (AA 484-518)

IL1RAP Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB57769 unconjugated
Produktnummer ABIN6242410
  • Target Alle IL1RAP Antikörper anzeigen
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Bindungsspezifität
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 484-518
    Reaktivität
    • 30
    • 12
    • 3
    Human, Maus
    Wirt
    • 33
    • 4
    Kaninchen
    Klonalität
    • 33
    • 4
    Polyklonal
    Konjugat
    • 25
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL1RAP Antikörper ist unkonjugiert
    Applikation
    • 24
    • 12
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    H
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 484-518 amino acids of human IL1RAP.
    Klon
    RB57769
    Isotyp
    IgG
    Top Product
    Discover our top product IL1RAP Primärantikörper
  • Applikationshinweise
    WB: 1:2000. IHC-P: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))
    Andere Bezeichnung
    IL1RAP (IL1RAP Produkte)
    Synonyme
    IL1RAP antikoerper, il-1racp antikoerper, il-racp antikoerper, il1r3 antikoerper, C3orf13 antikoerper, IL-1RAcP antikoerper, IL1R3 antikoerper, 6430709H04Rik antikoerper, AI255955 antikoerper, AV239853 antikoerper, IL-1RAcp antikoerper, Il1racpb antikoerper, interleukin 1 receptor accessory protein antikoerper, IL1RAP antikoerper, il1rap antikoerper, il-1racp antikoerper, Il1rap antikoerper
    Hintergrund
    Coreceptor for IL1RL2 in the IL-36 signaling system (,By similarity),. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
    Molekulargewicht
    65418
    UniProt
    Q9NPH3
    Pathways
    NF-kappaB Signalweg, Growth Factor Binding
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