ErbB2/Her2 Antikörper
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- Target Alle ErbB2/Her2 Antikörper anzeigen
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ErbB2/Her2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide of Human ERBB2
- Isotyp
- IgG
- Top Product
- Discover our top product ErbB2/Her2 Primärantikörper
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- Applikationshinweise
- WB:1:500-1:1000, IHC:1:50-1:100,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Store at -20 °C or -80 °C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid freeze / thaw cycles.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- Andere Bezeichnung
- ERBB2 (ErbB2/Her2 Produkte)
- Synonyme
- CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper
- Hintergrund
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Background: The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40 % of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222, phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway.
Aliases: Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, C erb B2/neu protein antibody, CD340 antibody, CD340 antigen antibody, Cerb B2/neu protein antibody, CerbB2 antibody, Erb b2 receptor tyrosine kinase 2 antibody, ErbB-2 proto-oncogene antibody, ERBB2 antibody, ERBB2_HUMAN antibody, HER 2 antibody, HER 2/NEU antibody, HER2 antibody, Herstatin antibody, Human epidermal growth factor receptor 2 antibody, Metastatic lymph node gene 19 protein antibody, MLN 19 antibody, MLN19 antibody, NEU antibody, NEU proto oncogene antibody, Neuro/glioblastoma derived oncogene homolog antibody, Neuroblastoma/glioblastoma derived oncogene homolog antibody, NGL antibody, p185erbB2 antibody, Proto-oncogene c-ErbB-2 antibody, Proto-oncogene Neu antibody, Receptor tyrosine-protein kinase erbB-2 antibody, TKR1 antibody, Tyrosine kinase type cell surface receptor HER2 antibody, Tyrosine kinase-type cell surface receptor HER2 antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody, V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody
- Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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