TNFRSF12A Antikörper

Produktnummer ABIN1888241

Produktdetails anti-TNFRSF12A Antikörper

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFRSF12A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: human IgG1 Fc-tagged Fn14 protein.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu TNFRSF12A

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Andere Bezeichnung: Fn14 (TNFRSF12A Produkte)

Synonyme: CD266 antikoerper, FN14 antikoerper, TWEAKR antikoerper, AI255180 antikoerper, C87282 antikoerper, Fn14 antikoerper, HPIP antikoerper, TWEAK-R antikoerper, TweakR antikoerper, TNF receptor superfamily member 12A antikoerper, tumor necrosis factor receptor superfamily, member 12a antikoerper, TNFRSF12A antikoerper, Tnfrsf12a antikoerper

Hintergrund: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis.These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily.Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules.Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas.In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.
Synonyms: Fibroblast growth factor-inducible 14, TNFRSF12, TWEAK-R

NCBI Accession: NP_057723

Pathways: Apoptose, Regulation of Cell Size