×
Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.
TNFRSF12A Antikörper
TNFRSF12A
Reaktivität: Human, Maus
WB, FACS, IHC (fro)
Wirt: Maus
Monoclonal
ITEM-4
unconjugated
Produktnummer ABIN2749054
Produktdetails anti-TNFRSF12A Antikörper
(ausblenden)
Target
Alle TNFRSF12A Antikörper anzeigen
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Reaktivität
Alle Reaktivitäten für TNFRSF12A Antikörper
Human, Maus
Wirt
Alle Wirte für TNFRSF12A Antikörper
Maus
Klonalität
Alle Klonalitäten für TNFRSF12A Antikörper
Monoklonal
Konjugat
Alle Konjugate für TNFRSF12A Antikörper
Dieser TNFRSF12A Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TNFRSF12A Antikörper
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
Spezifität
The mouse monoclonal antibody ITEM-4 recognizes an extracellular epitope of CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Kreuzreaktivität (Details)
Human, Mouse
Aufreinigung
Purified by protein-A affinity chromatography.
Reinheit
> 95 % (by SDS-PAGE)
Immunogen
human CD266-transfected P815 cells
Klon
ITEM-4
Isotyp
IgG2b
Top Product
Discover our top product TNFRSF12A Primärantikörper
Alternativen
(anzeigen)
anti-Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) (AA 104-118) antibody
TNFRSF12A
Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Pferd, Affe, Fledermaus, Hamster
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
(ausblenden)
Applikationshinweise
Flow cytometry: Recommended dilution: 1-4 μg/mL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
(ausblenden)
Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2-8°C. Do not freeze.
Referenzen für anti-TNFRSF12A Antikörper (ABIN2749054)
(ausblenden)
Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima : "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. " in: Experimental and therapeutic medicine , Vol. 2 , Issue 1 , pp. 103-108 , (2012 ) (PubMed ).
Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant : "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 185 , Issue 3 , pp. 1593-605 , (2010 ) (PubMed ).
Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita : "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 170 , Issue 1 , pp. 341-8 , (2002 ) (PubMed ).
Details zu TNFRSF12A
(ausblenden)
Target
TNFRSF12A
(Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))
Andere Bezeichnung
CD266 / TWEAK R (TNFRSF12A Produkte )
Synonyme
CD266 antikoerper, FN14 antikoerper, TWEAKR antikoerper, AI255180 antikoerper, C87282 antikoerper, Fn14 antikoerper, HPIP antikoerper, TWEAK-R antikoerper, TweakR antikoerper, TNF receptor superfamily member 12A antikoerper, tumor necrosis factor receptor superfamily, member 12a antikoerper, TNFRSF12A antikoerper, Tnfrsf12a antikoerper
Hintergrund
TNF receptor superfamily member 12A,CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.,TWEAKR, FN14, TNFRSF12A
Gen-ID
51330
UniProt
Q9NP84
Pathways
Apoptose , Regulation of Cell Size
Zuletzt angesehen
(ausblenden)