TIRAP
Reaktivität: Human
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung
Avoid freezing and thawing repeatly.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
TIRAP
(Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))
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Hintergrund
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling. Synonyms: MAL