Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) Antikörper

Produktnummer ABIN1887809

Produktdetails

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Ion exchange chromatography purified

Immunogen: Peptide corresponding to 14 amino acids near the middle of human NADE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Antigendetails

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Andere Bezeichnung: NADE (NGFRAP1 Produkte)

Synonyme: BEX3 antikoerper, Bex antikoerper, DXS6984E antikoerper, HGR74 antikoerper, NADE antikoerper, NGFRAP1 antikoerper, LNGFR antikoerper, Tnfrsf16 antikoerper, p75 antikoerper, p75NGFR antikoerper, p75NTR antikoerper, AL033356 antikoerper, Bex3 antikoerper, DXWsu67e antikoerper, Gcap27 antikoerper, Nade antikoerper, WBP5 antikoerper, brain expressed X-linked 3 antikoerper, nerve growth factor receptor (TNFR superfamily, member 16) antikoerper, BEX3 antikoerper, Ngfr antikoerper, Bex3 antikoerper

Hintergrund: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF).The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR.Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac).Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization.It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed.Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

NCBI Accession: NP_996798

Pathways: Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity