Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) Antikörper

Produktnummer ABIN500304

Produktdetails

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects NADE / BEX3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Ion exchange chromatography

Immunogen: NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, NADE migrates at approx. 23 kDa in SDS-PAGE. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Antigendetails

Target: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Andere Bezeichnung: NADE / BEX3 (NGFRAP1 Produkte)

Synonyme: BEX3 antikoerper, Bex antikoerper, DXS6984E antikoerper, HGR74 antikoerper, NADE antikoerper, NGFRAP1 antikoerper, LNGFR antikoerper, Tnfrsf16 antikoerper, p75 antikoerper, p75NGFR antikoerper, p75NTR antikoerper, AL033356 antikoerper, Bex3 antikoerper, DXWsu67e antikoerper, Gcap27 antikoerper, Nade antikoerper, WBP5 antikoerper, brain expressed X-linked 3 antikoerper, nerve growth factor receptor (TNFR superfamily, member 16) antikoerper, BEX3 antikoerper, Ngfr antikoerper, Bex3 antikoerper

Hintergrund: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).Synonyms: Brain-expressed X-linked protein 3, DXS6984E, NGFRAP1, p75NTR-associated cell death executor

Gen-ID: 27018

NCBI Accession: NP_996798

UniProt: Q00994

Pathways: Neurotrophin Signalübertragung, Positive Regulation of Endopeptidase Activity