TIRAP Antikörper (C-Term)

Produktnummer ABIN1887377

Produktdetails anti-TIRAP Antikörper

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIRAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu TIRAP

Target: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Andere Bezeichnung: TIRAP (TIRAP Produkte)

Synonyme: mal antikoerper, wyatt antikoerper, BACTS1 antikoerper, Mal antikoerper, MyD88-2 antikoerper, AA407980 antikoerper, C130027E04Rik antikoerper, Tlr4ap antikoerper, Wyatt antikoerper, toll-interleukin 1 receptor (TIR) domain containing adaptor protein antikoerper, TIR domain containing adaptor protein antikoerper, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog antikoerper, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein antikoerper, tirap antikoerper, TIRAP antikoerper, tirap.L antikoerper, Tirap antikoerper

Hintergrund: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades