PRDM16 Antikörper (C-Term)

Produktnummer ABIN1887173

Produktdetails anti-PRDM16 Antikörper

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM16 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid peptide from near the carboxy terminus of human PRDM16.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu PRDM16

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Andere Bezeichnung: PRDM16 (PRDM16 Produkte)

Synonyme: PRDM16 antikoerper, wu:fc09g08 antikoerper, MEL1 antikoerper, PFM13 antikoerper, 5730557K01Rik antikoerper, C130091E20 antikoerper, csp1 antikoerper, mKIAA1675 antikoerper, mel1 antikoerper, PR/SET domain 16 antikoerper, PR domain containing 16 antikoerper, PRDM16 antikoerper, prdm16 antikoerper, Prdm16 antikoerper

Hintergrund: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain.The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML.The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML.Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway.Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
Synonyms: PR domain containing 16, MEL1, PFM13

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation