PRDM16 Antikörper (C-Term)

Produktnummer ABIN500533

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PRDM16 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PRDM16 Antikörper (C-Term) (ABIN500533)

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRDM16 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PRDM16 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat

Aufreinigung: Peptide Affinity Chromatography

Immunogen: PRDM16 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of Human PRDM16.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections. Positive Control: Rat Brain Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt store the antibody (in aliquots) at -20 °C.

Details zu PRDM16

Target: PRDM16 (PR Domain Containing 16 (PRDM16))

Andere Bezeichnung: PRDM16

Hintergrund: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.Synonyms: KIAA1675, MDS1/EVI1-like gene 1, MEL1, PFM13, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1

Gen-ID: 63976

UniProt: Q9HAZ2

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation