SOCS1 Antikörper (C-Term)

Produktnummer ABIN1887030

Produktdetails anti-SOCS1 Antikörper

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the carboxy terminus of human SOCS1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Andere Bezeichnung: SOCS1 (SOCS1 Produkte)

Synonyme: socs1 antikoerper, zgc:91868 antikoerper, jab antikoerper, cis1 antikoerper, ssi1 antikoerper, tip3 antikoerper, cish1 antikoerper, ssi-1 antikoerper, socs-1 antikoerper, SOCS1 antikoerper, LOC100228306 antikoerper, socs1b antikoerper, CIS1 antikoerper, CISH1 antikoerper, JAB antikoerper, SOCS-1 antikoerper, SSI-1 antikoerper, SSI1 antikoerper, TIP3 antikoerper, Cish1 antikoerper, Cish7 antikoerper, Socs-1 antikoerper, suppressor of cytokine signaling 1a antikoerper, suppressor of cytokine signaling 1 antikoerper, suppressor of cytokine signaling 1 L homeolog antikoerper, socs1a antikoerper, socs1 antikoerper, SOCS1 antikoerper, socs1.L antikoerper, Socs1 antikoerper

Hintergrund: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines.SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase.SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
Synonyms: Suppressor of cytokine signaling 1, JAK-binding protein, JAB

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, TLR Signalweg, Response to Growth Hormone Stimulus