TANK
Reaktivität: Human
WB, IF, EIA
Wirt: Kaninchen
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung
Avoid freezing and thawing repeatly.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Target
TANK
(TRAF Family Member-Associated NFKB Activator (TANK))
I-TRAF antikoerper, ITRAF antikoerper, TRAF2 antikoerper, C86182 antikoerper, E430026L09Rik antikoerper, zgc:153048 antikoerper, i-traf antikoerper, tank antikoerper, traf2 antikoerper, TRAF family member associated NFKB activator antikoerper, TRAF family member-associated Nf-kappa B activator antikoerper, TRAF family member-associated NFKB activator antikoerper, TRAF family member associated NFKB activator L homeolog antikoerper, TANK antikoerper, Tank antikoerper, tank antikoerper, tank.L antikoerper
Hintergrund
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction.Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB.This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1.More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex.This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins.At least two isoforms of TANK are known to exist. Synonyms: TRAF family member-associated NF-kappaB activator, I-TRAF