PIK3C3 Antikörper (N-Term)

Produktnummer ABIN1882112

Produktdetails anti-PIK3C3 Antikörper

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Bindungsspezifität: AA 9-41, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3C3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M, Pig, Rat, X

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PI3KC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-41 amino acids from the N-terminal region of human PI3KC3.

Klon: RB10852

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PIK3C3 Antikörper (ABIN1882112)

Wang, Whiteman, Lian, Wang, Singh, Huang, Denmark: "A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21412-24, (2009) (PubMed).

Vergne, Chua, Deretic: "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade." in: The Journal of experimental medicine, Vol. 198, Issue 4, pp. 653-9, (2003) (PubMed).

Volinia, Dhand, Vanhaesebroeck, MacDougall, Stein, Zvelebil, Domin, Panaretou, Waterfield: "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system." in: The EMBO journal, Vol. 14, Issue 14, pp. 3339-48, (1995) (PubMed).

Details zu PIK3C3

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Abstract: PIK3C3 Produkte

Synonyme: im:7147158 antikoerper, wu:fc13g06 antikoerper, wu:fz51e12 antikoerper, zgc:112016 antikoerper, zgc:113009 antikoerper, VPS34 antikoerper, hVps34 antikoerper, 5330434F23Rik antikoerper, Vps34 antikoerper, phosphatidylinositol 3-kinase catalytic subunit type 3 antikoerper, phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog antikoerper, phosphatidylinositol 3-kinase, catalytic subunit type 3 antikoerper, PIK3C3 antikoerper, pik3c3.L antikoerper, pik3c3 antikoerper, Pik3c3 antikoerper

Hintergrund: PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

Molekulargewicht: 101549

NCBI Accession: NP_002638

UniProt: Q8NEB9

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagie