FGFR1 Antikörper (N-Term)

Produktnummer ABIN1882081

Produktdetails anti-FGFR1 Antikörper

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Bindungsspezifität: AA 19-48, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~48 amino acids from the N-terminal region of human FGFR1.

Klon: RB04521

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:50~100. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-FGFR1 Antikörper (ABIN1882081)

Hirata, Katayama, Tsuji, Imura, Natsume, Sugahara, Kunieda, Nakamura, Otsuki: "Homeobox family Hoxc localization during murine palate formation." in: Congenital anomalies, Vol. 56, Issue 4, pp. 172-9, (2016) (PubMed).

Mohanan, Temburni, Kappes, Galileo: "L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor." in: Clinical & experimental metastasis, Vol. 30, Issue 4, pp. 507-20, (2013) (PubMed).

Kamura, Matsumoto, Fukushi, Fujiwara, Iida, Okada, Iwamoto: "Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway." in: British journal of cancer, Vol. 103, Issue 3, pp. 370-81, (2010) (PubMed).

Page, Ambady, Holmes, Vilner, Kole, Kashpur, Huntress, Vojtic, Whitton, Dominko: "Induction of stem cell gene expression in adult human fibroblasts without transgenes." in: Cloning and stem cells, Vol. 11, Issue 3, pp. 417-26, (2009) (PubMed).

Mondrinos, Koutzaki, Lelkes, Finck: "A tissue-engineered model of fetal distal lung tissue." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 293, Issue 3, pp. L639-50, (2007) (PubMed).

Sahni, Francis: "Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3." in: Blood, Vol. 104, Issue 12, pp. 3635-41, (2004) (PubMed).

Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: "Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite." in: Archives of biochemistry and biophysics, Vol. 410, Issue 2, pp. 187-200, (2003) (PubMed).

Fu, Abu-Khalil, Morrison, Geschwind, Kornblum: "Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain." in: The Journal of comparative neurology, Vol. 462, Issue 2, pp. 265-73, (2003) (PubMed).

Lundin, Rönnstrand, Cross, Hellberg, Lindahl, Claesson-Welsh: "Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin." in: Experimental cell research, Vol. 287, Issue 1, pp. 190-8, (2003) (PubMed).

Kiselyov, Skladchikova, Hinsby, Jensen, Kulahin, Soroka, Pedersen, Tsetlin, Poulsen, Berezin, Bock: "Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP." in: Structure (London, England : 1993), Vol. 11, Issue 6, pp. 691-701, (2003) (PubMed).

Baumann, Kunapuli, Tracy, Cowell: "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16198-208, (2003) (PubMed).

Hauge: "[Expeditions to high altitudes--what can we learn from them?]." in: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Vol. 111, Issue 8, pp. 926-8, (1991) (PubMed).

Details zu FGFR1

Target: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Andere Bezeichnung: FGFR1 (FGFR1 Produkte)

Synonyme: FGFR antikoerper, fgfr antikoerper, X1FGFR antikoerper, XFGFR-1 antikoerper, XFGFRA2 antikoerper, bfgfr antikoerper, cek antikoerper, fgfr1 antikoerper, flg antikoerper, flt-2 antikoerper, flt2 antikoerper, kal2 antikoerper, ogd antikoerper, xfgfr1 antikoerper, CG7223 antikoerper, CT22273 antikoerper, CT39172 antikoerper, DFGF-R1 antikoerper, DFGF-R2 antikoerper, DFR-1 antikoerper, DFR1 antikoerper, DFR1/DFGF-R2 antikoerper, DPR3 antikoerper, DTRK(FR1) antikoerper, Dfr-1 antikoerper, Dfr1 antikoerper, DmHD-38 antikoerper, Dmel\\CG7223 antikoerper, Dtk1 antikoerper, EMS2 antikoerper, FGF-R2 antikoerper, FGFR2 antikoerper, FR1 antikoerper, Fr1 antikoerper, HD-38 antikoerper, HTL/FGFR1 antikoerper, Htl antikoerper, Tk1 antikoerper, dtk1 antikoerper, i100 antikoerper, i150 antikoerper, i79 antikoerper, j372 antikoerper, cd331 antikoerper, fgfbr antikoerper, fgfr-1 antikoerper, hbgfr antikoerper, n-sam antikoerper, ach antikoerper, cd333 antikoerper, cek2 antikoerper, fgfr-3 antikoerper, hsfgfr3ex antikoerper, jtk4 antikoerper, BFGFR antikoerper, CD331 antikoerper, CEK antikoerper, FGFBR antikoerper, FGFR-1 antikoerper, FLG antikoerper, FLT-2 antikoerper, FLT2 antikoerper, HBGFR antikoerper, HH2 antikoerper, KAL2 antikoerper, N-SAM antikoerper, OGD antikoerper, bFGF-R-1 antikoerper, AW208770 antikoerper, Eask antikoerper, Fgfr-1 antikoerper, Flt-2 antikoerper, Hspy antikoerper, FLG-1 antikoerper, FGFRI antikoerper, x1fgfr antikoerper, cb231 antikoerper, sb:cb231 antikoerper, fibroblast growth factor receptor antikoerper, fibroblast growth factor receptor 1 S homeolog antikoerper, basic fibroblast growth factor receptor 1 antikoerper, heartless antikoerper, fibroblast growth factor receptor 1 antikoerper, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog antikoerper, Fibroblast growth factor receptor 1 antikoerper, fibroblast growth factor receptor 1 L homeolog antikoerper, fibroblast growth factor receptor 1a antikoerper, FGFR antikoerper, fgfr antikoerper, fgfr1.S antikoerper, CpipJ_CPIJ005849 antikoerper, htl antikoerper, fgfr1 antikoerper, fgfr3.L antikoerper, FGFR1 antikoerper, Fgfr1 antikoerper, fgfr1.L antikoerper, fgfr1a antikoerper

Hintergrund: FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.

Molekulargewicht: 91868

NCBI Accession: NP_001167534, NP_001167535, NP_001167536, NP_001167537, NP_001167538, NP_056934, NP_075593, NP_075594, NP_075598

UniProt: P11362

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteine