PPP2R1A Antikörper (C-Term)

Produktnummer ABIN1881682

Produktdetails anti-PPP2R1A Antikörper

Target: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Bindungsspezifität: AA 454-481, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP2R1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, M, Pig

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PPP2R1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-481 amino acids from the C-terminal region of human PPP2R1A.

Klon: RB41029

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PPP2R1A Antikörper (ABIN1881682)

Jones, Wang, Shih, Mao, Nakayama, Roden, Glas, Slamon, Diaz, Vogelstein, Kinzler, Velculescu, Papadopoulos: "Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma." in: Science (New York, N.Y.), Vol. 330, Issue 6001, pp. 228-31, (2010) (PubMed).

Schmitz, Held, Janssens, Hutchins, Hudecz, Ivanova, Goris, Trinkle-Mulcahy, Lamond, Poser, Hyman, Mechtler, Peters, Gerlich: "Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells." in: Nature cell biology, Vol. 12, Issue 9, pp. 886-93, (2010) (PubMed).

Dupont, Breyer, Bradley, Schuyler, Plummer, Sanders, Page, Smith: "Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk." in: Cancer, Vol. 116, Issue 1, pp. 8-19, (2010) (PubMed).

Heikkinen, Nummela, Leivonen, Westermarck, Hill, Kähäri, Jaakkola: "Hypoxia-activated Smad3-specific dephosphorylation by PP2A." in: The Journal of biological chemistry, Vol. 285, Issue 6, pp. 3740-9, (2010) (PubMed).

Wang, Gao, Wang, Flagg, Deng: "A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 10, pp. 1012-21, (2009) (PubMed).

Details zu PPP2R1A

Target: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Andere Bezeichnung: PPP2R1A (PPP2R1A Produkte)

Synonyme: PP2A-Aalpha antikoerper, PP2AAALPHA antikoerper, PR65A antikoerper, PR65 antikoerper, pp2a-aalpha antikoerper, pp2aaalpha antikoerper, ppp2r1a antikoerper, pr65a antikoerper, wu:fa02h04 antikoerper, zgc:56296 antikoerper, 6330556D22Rik antikoerper, PP2A antikoerper, ppp2r1a-a antikoerper, ppp2r1a-b antikoerper, protein phosphatase 2 scaffold subunit Aalpha antikoerper, protein phosphatase 2 scaffold subunit A alpha antikoerper, protein phosphatase 2 regulatory subunit A, alpha L homeolog antikoerper, protein phosphatase 2 regulatory subunit A, alpha antikoerper, protein phosphatase 2, regulatory subunit A, beta a antikoerper, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform antikoerper, protein phosphatase 2, regulatory subunit A, alpha isoform antikoerper, protein phosphatase 2, regulatory subunit A, alpha antikoerper, protein phosphatase 2 regulatory subunit A, alpha S homeolog antikoerper, PPP2R1A antikoerper, Ppp2r1a antikoerper, ppp2r1a.L antikoerper, ppp2r1a antikoerper, ppp2r1ba antikoerper, LOC583227 antikoerper, ppp2r1a.S antikoerper

Hintergrund: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq].

Molekulargewicht: 65309

NCBI Accession: NP_055040

UniProt: P30153

Pathways: PI3K-Akt Signalweg, Mitotic G1-G1/S Phases, M Phase, Hepatitis C, Toll-Like Receptors Cascades