IKK alpha Antikörper (C-Term)

Produktnummer ABIN1881204

Dieses Anti-IKK alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IKK alpha in WB. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für IKK alpha Antikörper (C-Term) (ABIN1881204)

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKK alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41164

Produktdetails anti-IKK alpha Antikörper

Bindungsspezifität: AA 553-582, C-Term

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human CHUK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-IKK alpha Antikörper (ABIN1881204)

Lahtela, Nousiainen, Stefanovic, Tallila, Viskari, Karikoski, Gentile, Saloranta, Varilo, Salonen, Kestilä: "Mutant CHUK and severe fetal encasement malformation." in: The New England journal of medicine, Vol. 363, Issue 17, pp. 1631-7, (2010) (PubMed).

Gouin, Adib-Conquy, Balestrino, Nahori, Villiers, Colland, Dramsi, Dussurget, Cossart: "The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 40, pp. 17333-8, (2010) (PubMed).

Cummins, Oliver, Lenihan, Fitzpatrick, Bruning, Scholz, Slattery, Leonard, McLoughlin, Taylor: "NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4439-45, (2010) (PubMed).

Li, Morgan, Choksi, Zhang, Kim, Liu: "MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation." in: Nature immunology, Vol. 11, Issue 9, pp. 799-805, (2010) (PubMed).

Rotman, Koh, Zmuda, Kleiner, Liang: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, (2010) (PubMed).

Details zu IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Andere Bezeichnung: CHUK

Hintergrund: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Molekulargewicht: 84640

NCBI Accession: NP_001269

UniProt: O15111

Pathways: PI3K-Akt Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine