IKK alpha Antikörper (AA 411-745)

Produktnummer ABIN3030568

Produktdetails anti-IKK alpha Antikörper

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Bindungsspezifität: AA 411-745

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IKK alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 411-745) was used as the immunogen for this IKK alpha antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the IKK alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the IKK alpha antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu IKK alpha

Target: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Andere Bezeichnung: IKK alpha (CHUK Produkte)

Synonyme: ikk antikoerper, ikk1 antikoerper, ikka antikoerper, ikkalpha antikoerper, CHUK antikoerper, IKBKA antikoerper, IKK-alpha antikoerper, IKK1 antikoerper, IKKA antikoerper, NFKBIKA antikoerper, TCF16 antikoerper, AI256658 antikoerper, Chuk1 antikoerper, Fbx24 antikoerper, Fbxo24 antikoerper, Ikka antikoerper, zgc:56539 antikoerper, conserved helix-loop-helix ubiquitous kinase S homeolog antikoerper, conserved helix-loop-helix ubiquitous kinase antikoerper, chuk.S antikoerper, CHUK antikoerper, Chuk antikoerper, chuk antikoerper

Hintergrund: Inhibitor of nuclear factor kappa-B kinase subunit alpha, also known as conserved helix-loop-helix ubiquitous kinase (CHUK) or IKBKA, is a protein kinase that in humans is encoded by the CHUK gene. It is mapped to 10q24.31. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. IKK alpha is part of the IkB kinase complex that plays an important role in regulating the NF-kB transcription factor. IKK alpha also has many additional cellular targets, and is thought to function independently of the NF-kB pathway to regulate epidermal differentiation.

Gen-ID: 1147

Pathways: PI3K-Akt Signalweg, NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine