DYNLL1 Antikörper (Cytoplasmic)

Produktnummer ABIN187402

Produktdetails anti-DYNLL1 Antikörper

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Bindungsspezifität: Cytoplasmic

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser DYNLL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Spezifität: Recognizes human and mouse DLC1. Does not cross-react with DLC2. Species Reactivity: Mouse and human. Others not tested.

Immunogen: Recombinant mouse DLC1 [LC8, PIN].

Klon: 10D6

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Western blot: use at least a 1:1,000 dilution. The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL.

Buffer: 100 µg affinity purified antibody in PBS containing 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu DYNLL1

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Andere Bezeichnung: DYNLL1 (DYNLL1 Produkte)

Synonyme: DLC1 antikoerper, DLC8 antikoerper, DNCL1 antikoerper, DNCLC1 antikoerper, LC8 antikoerper, LC8a antikoerper, PIN antikoerper, hdlc1 antikoerper, dynll2 antikoerper, wu:fd56c09 antikoerper, zgc:73406 antikoerper, Dlc8 antikoerper, Dnclc1 antikoerper, Pin antikoerper, 8kDLC antikoerper, lc8 antikoerper, dlc1 antikoerper, dlc8 antikoerper, lc8a antikoerper, dncl1 antikoerper, dnclc1 antikoerper, dynll1a antikoerper, MGC68763 antikoerper, CDLC2 antikoerper, dynll1 antikoerper, dynll1b antikoerper, pin antikoerper, MGC89636 antikoerper, dynein light chain LC8-type 1 antikoerper, dynein, light chain, LC8-type 1 antikoerper, dynein light chain LC8-type 1 S homeolog antikoerper, dynein light chain LC8-type 1 L homeolog antikoerper, Dynein light chain 1, cytoplasmic antikoerper, DYNLL1 antikoerper, dynll1 antikoerper, Dynll1 antikoerper, dynll1.S antikoerper, dynll1.L antikoerper, dlc-1 antikoerper

Hintergrund: The 10 kDa dynein light chain 1 (DLC1, LC8), also known as neuronal nitric oxide synthase inhibitory protein or PIN (protein inhibitor of nNOS), is a component of cytoplasmic dynein, which is involved in the minus end-directed movement of organelles along microtubules. It is a highly conserved protein that is associated with the microtubular dynein motor complex by its binding to dynein intermediate chain (DIC). This allows DLC1 to act as a cargo protein, hooking many different proteins to the dynein motor complex. Binding of the BH3-only protein, Bim, to DLC1 also controls its pro-apoptotic activity. In healthy cells, most Bim molecules are sequestered from Bcl-2 and its homologs by DLC1 mediated binding to the dynein motor complex. Certain apoptotic signals, such as cytokine withdrawal or deregulated calcium flux, induces the release of Bim and DLC1 from the dynein motor complex. This allows Bim and DLC1 to translocate and bind to Bcl-2 and its homologs, thus neutralizing their anti-apoptotic activity.

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity