Lipoprotein Lipase Antikörper (AA 380-410)

Produktnummer ABIN1820143

Produktdetails anti-Lipoprotein Lipase Antikörper

Target: Lipoprotein Lipase (LPL)

Bindungsspezifität: AA 380-410

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Meerschweinchen, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lipoprotein Lipase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Functional Studies (Func)

Spezifität: Recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Clone 5D2 has been shown to inhibit the activity of human LPL(2,3), and is widely used in human studies.

Keine Kreuzreaktivität: Maus

Aufreinigung: Protein G purified

Endotoxin-Niveau: Low Endotoxin

Immunogen: Purified bovine milk lipoprotein lipase.

Type of Immunogen: Purified protein

Klon: 5D2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (1:500 - 1:5000), Func, IP, WB

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Kommentare:

Target Species of Antibody: Bovine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze-thaw cycles.

Details zu Lipoprotein Lipase

Target: Lipoprotein Lipase (LPL)

Andere Bezeichnung: Lipoprotein Lipase / LPL (LPL Produkte)

Synonyme: HDLCQ11 antikoerper, LIPD antikoerper, fb62e04 antikoerper, fc49b03 antikoerper, wu:fb62e04 antikoerper, wu:fc49b03 antikoerper, LPL antikoerper, lipd antikoerper, hdlcq11 antikoerper, lpl antikoerper, LOC100223817 antikoerper, lipoprotein lipase antikoerper, LPL antikoerper, Lpl antikoerper, lpl antikoerper

Hintergrund: Name/Gene ID: LPL

Synonyms: LPL, LIPD, Lipoprotein lipase, HDLCQ11

Gen-ID: 4023

Pathways: Lipid Metabolism