SF3B1 Antikörper (AA 1-100)

Produktnummer ABIN1713892

Produktdetails anti-SF3B1 Antikörper

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Bindungsspezifität: AA 1-100

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SF3B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAP155/SF3B1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SF3B1

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Andere Bezeichnung: SAP155 (SF3B1 Produkte)

Synonyme: Cus1 antikoerper, SAP145 antikoerper, SF3B145 antikoerper, SF3b1 antikoerper, SF3b150 antikoerper, Hsh155 antikoerper, MDS antikoerper, PRP10 antikoerper, PRPF10 antikoerper, SAP155 antikoerper, SF3b155 antikoerper, 155kDa antikoerper, 2810001M05Rik antikoerper, AA409119 antikoerper, Prp10 antikoerper, TA-8 antikoerper, Targ4 antikoerper, hsh155 antikoerper, prp10 antikoerper, prpf10 antikoerper, sap155 antikoerper, SF3B1 antikoerper, Sap155 antikoerper, wu:fb99f09 antikoerper, splicing factor 3b subunit 2 antikoerper, splicing factor 3b subunit 1 antikoerper, splicing factor 3b, subunit 1 antikoerper, splicing factor 3b subunit 1 S homeolog antikoerper, SF3B2 antikoerper, SF3B1 antikoerper, Sf3b1 antikoerper, sf3b1.S antikoerper, sf3b1 antikoerper

Hintergrund:

Synonyms: Hsh 155, MDS, Pre mRNA processing 10, Pre mRNA splicing factor SF3b 155 kDa subunit, PRP 10, PRP10, PRPF 10, PRPF10, SAP 155, SAP155, SF3B 1, SF3B 1, SF3b155, Spliceosome associated protein 155, Splicing factor 3b subunit 1 155 kDa, Splicing factor 3B subunit 1, SF3B1_HUMAN.

Background: SAP 155 is a 1,304 amino acid member of the SF3B1 family and contains eleven HEAT repeats. Localized to nuclear speckles and also to the cytoplasm during mitosis, SAP 155 is a subunit of the SF3B splicing factor. The SF3B splicing factor is a U2 snRNP-associated protein complex essential for spliceosome assembly. SF3B contains the spliceosomal proteins SAP 49, SAP 130, SAP 145 and SAP 155. Concomitant with splicing catalysis, SAP 155 is phosphorylated at its N-terminal Thr-Pro dipeptide motifs by Dyrk1A and cyclin E/Cdk2. This modification of SAP 155 is vital for a functional spliceosome as it is an essential event in the basic splicing reaction. Due to alternative splicing events, various SAP 155 isoforms are produced.

Gen-ID: 23451

Pathways: Chromatin Binding