SF3B1 Antikörper (AA 98-198)
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- Target Alle SF3B1 Antikörper anzeigen
- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
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Bindungsspezifität
- AA 98-198
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser SF3B1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
- Spezifität
- This antibody reacts with Sap155.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse
- Aufreinigung
- Protein A agarose
- Immunogen
- Recombinant GST-Sap155 (98 a.a.- 198 a.a.)
- Klon
- 16
- Isotyp
- IgG2b
- Top Product
- Discover our top product SF3B1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
- Konservierungsmittel
- Without preservative
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Upon receipt, store (in aliqouts) at -20 °C.
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability." in: Cell reports, Vol. 28, Issue 6, pp. 1551-1563.e7, (2020) (PubMed).
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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability." in: Cell reports, Vol. 28, Issue 6, pp. 1551-1563.e7, (2020) (PubMed).
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- Target
- SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))
- Andere Bezeichnung
- SF3B1 / SAP155 (SF3B1 Produkte)
- Synonyme
- Cus1 antikoerper, SAP145 antikoerper, SF3B145 antikoerper, SF3b1 antikoerper, SF3b150 antikoerper, Hsh155 antikoerper, MDS antikoerper, PRP10 antikoerper, PRPF10 antikoerper, SAP155 antikoerper, SF3b155 antikoerper, 155kDa antikoerper, 2810001M05Rik antikoerper, AA409119 antikoerper, Prp10 antikoerper, TA-8 antikoerper, Targ4 antikoerper, hsh155 antikoerper, prp10 antikoerper, prpf10 antikoerper, sap155 antikoerper, SF3B1 antikoerper, Sap155 antikoerper, wu:fb99f09 antikoerper, splicing factor 3b subunit 2 antikoerper, splicing factor 3b subunit 1 antikoerper, splicing factor 3b, subunit 1 antikoerper, splicing factor 3b subunit 1 S homeolog antikoerper, SF3B2 antikoerper, SF3B1 antikoerper, Sf3b1 antikoerper, sf3b1.S antikoerper, sf3b1 antikoerper
- Hintergrund
- SF3 is a U2 snRNP-associated protein complex essential for spliceosome assembly and splicing catalysis of the majo r spliceosome. SF3 contains the Spliceosome-Associated Proteins, Sap 49, 130, 145, and 155. Sap155/Sf3b1 is an essential subunit of the U2 snRNP for mRNA splicing and has also been identified in the minor (U12-dependent) sp liceosome. Sap155 interacts with the mammalian PcG (Polycomb group) proteins, Mel18 and Ring1B by the yeast two hybrid system. Sap155 contains numerous Cdk consensus phosphorylation sites in its N terminus and is phosphorylated prior to catal ytic step II of the splicing pathway. Sap155 serves as a substrate for cyclin E-cdk2 in vitro , suggesting that pre-mRNA splicing may be linked to the cell cycle machiner y in mammalian cells.Synonyms: Pre-mRNA-splicing factor SF3b 155 kDa subunit, SAP 155, SAP-155, SF3b155, Spliceosome-associated protein 155, Splicing factor 3B subunit 1
- Molekulargewicht
- 155 kDa
- Gen-ID
- 23451
- NCBI Accession
- NP_036565
- UniProt
- O75533
- Pathways
- Chromatin Binding
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