TARDBP Antikörper

Produktnummer ABIN1580460

Produktdetails anti-TARDBP Antikörper

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TARDBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Aufreinigung: affinity purified antibody

Klon: 3H8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: The antibody will work at dilutions of 1:5,000 on sections and cells in tissue culture and 1:20,000 on western blots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4°C short term or -20°C long term.

Details zu TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Andere Bezeichnung: Tar DNA binding protein 43 (TARDBP Produkte)

Synonyme: TARDBP antikoerper, TDP43 antikoerper, DKFZp459I2127 antikoerper, tardbp antikoerper, ALS10 antikoerper, TDP-43 antikoerper, 1190002A23Rik antikoerper, C85084 antikoerper, Tdp43 antikoerper, wu:fb77f02 antikoerper, wu:fc52g10 antikoerper, TAR DNA binding protein antikoerper, Tardbp protein antikoerper, TAR DNA binding protein L homeolog antikoerper, TAR DNA-binding protein 43-like antikoerper, TARDBP antikoerper, tardbp antikoerper, tardbp.L antikoerper, Tardbp antikoerper, LOC100621383 antikoerper

Hintergrund: TDP43 was originally identified as a protein which binds to the transactivation response (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. UV cross-linking of HeLa cell extract revealed a 43 kDa protein which was cloned and sequenced and shown to contain a two copies of the approx. 90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. It also has a single Zinc Finger domain of the ZnF_RBZ subtype found in Ran binding proteins. Ran is a small G protein related to p21-Ras which regulates the import and export of proteins to the nucleus. The protein is frequently refered to by the acronym TDP43 corresponds to TAR DNA binding protein of molecular weight 43 kDa, although the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) name is TARDBP. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (ALS, 2). The protein is present in these inclusions in a partially degraded, hyperphosphorylated and ubiquitinated form. This antibody has been used in a recent peer reviewed publication, showing that it works well on western blots and on histological sections. Further images of histological staining using this antibody showing clears staining of ALS related inclusion bodies is shown here. The HGNC name for this protein is TARDBP.

Pathways: Positive Regulation of Peptide Hormone Secretion