HLA-B Antikörper (AA 62-90)

Produktnummer ABIN1539972

Produktdetails anti-HLA-B Antikörper

Target: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Bindungsspezifität: AA 62-90

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This HLA-B antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from human HLA-B.

Klon: 528CT10-4-1

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:100~250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: HLA-B Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu HLA-B

Target: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Andere Bezeichnung: HLA-B (HLA-B Produkte)

Synonyme: AS antikoerper, HLAB antikoerper, SPDA1 antikoerper, mhc1b antikoerper, major histocompatibility complex, class I, B antikoerper, major histocompatibility complex nonclassical class Ib L homeolog antikoerper, HLA-B antikoerper, BOLA-B antikoerper, MAMU-B18 antikoerper, DKFZP469N1225 antikoerper, mhc1b.L antikoerper

Hintergrund: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Gen-ID: 3106

UniProt: P03989

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints